Male Birth Control Pill Blocks 'Sperm Hormones,' But Will It Work?

20 March, 2018, 04:50 | Author: Homer Porter
  • A contraceptive pill for men has come a step closer to development. Taken daily like the female Pill it switches off a man¿s testosterone and the hormones that cause sperm production

Results of the UW study showed very few of the man "reported symptoms consistent with testosterone deficiency or excess". "We did see mild weight gain and an increase in cholesterol levels and that may require us to fine tune the dosing, but overall we are very encouraged about the safety profile of dimethandrolone", she said in a report in MedPageToday.

The good news is that there are various reversible male birth control prototypes now undergoing clinical trials.

For now, even though the Male Contraceptive Initiative has provided a $US150,000 grant for the scientists to move into the next phase of developing the drug, Dr Ventura said how quick the pill is developed and released would depend on more funding.

"DMAU is a major step forward in the development of a once-daily "male pill", said Stephanie Page, M.D., PhD, professor of medicine at the University of Washington.

The trials showed the pill can be given safely for more than one dose, but did not yet test for its success as contraception.

Once the tests were completed, the researchers found that the men who were given the 400-milligram doses had significantly lower testosterone levels, with two gonadotropins, or hormones used in sperm production, successfully suppressed.

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A male pill could be on the horizon after early trials showed a once-daily tablet was safe and appeared to work, according to researchers.

This new pill has overcome some previous challenges facing male birth control, like damage to the liver and other parts of the body.

The results from the new DMAU study will be presented Sunday March 18 at ENDO 2018, the Endocrine Society's 100th annual meeting in Chicago, Ill. "These promising results are unprecedented in the development of a prototype male pill". The men gained between 3 and 9 pounds, and their HDL or "good" cholesterol levels fell slightly - something that might, over time, raise heart disease risk. This led to effective contraception. Then they'll have to test it in men who are married or in other long-term relationships with women. The researchers said in order for the pills to be effective, they must be taken with food.

"Our last great advance in male contraception was 300 years ago with the development of the condom".

"We're often asked if there was a contraceptive if men would be interested in using it", Page said. The pills need to be taken with food to be effective, she said. To salvage the situation, men would also now have an option to take a drug that prevents pregnancy, thanks to a male contraceptive pill that is being developed towards that regard.


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